The Clinical Significance of Tumor MIR-122, -155, -182, and -200b Expression in Patients with Breast Cancer

Authors

  • V.F. Chekhun Kavetsky Institute of Experimental Pathology, Oncology, and Radiobiology, the NAS of Ukraine
  • N.Yu. Lukianova Kavetsky Institute of Experimental Pathology, Oncology, and Radiobiology, the NAS of Ukraine
  • T.V. Borikun Kavetsky Institute of Experimental Pathology, Oncology, and Radiobiology, the NAS of Ukraine
  • N.A. Bezdenezhnykh Kavetsky Institute of Experimental Pathology, Oncology, and Radiobiology, the NAS of Ukraine
  • I.V. Shepelenko Kavetsky Institute of Experimental Pathology, Oncology, and Radiobiology, the NAS of Ukraine
  • V.M. Bazas Kyiv City Clinical Oncological Center
  • A.N. Klyusov Kyiv City Clinical Oncological Center

DOI:

https://doi.org/10.15407/scine13.05.063

Keywords:

breast cancer, clinical significance, microRNAs

Abstract

The research was aimed at identifying the relationship between the oncogenic (-182, -155) and the onco-suppressive (-122, -200b) microRNAs in tumor cells with clinical and pathological characteristics of breast cancer (BC) and at establishing their clinical significance. MicroRNA levels have been determined by reverse transcription polymerase chain reaction (RT-PCR) in real time. The expression of estrogen (ER) and progesterone (PR) receptors, and Her2/neuepidermal growth factor has been ascertained by immunohistochemical method. The relationship of these microRNAs expression with the disease stage, the presence of metastatic lesions of regional lymph nodes, the differentiation degree, and the tumor molecular subtype has been established. The obtained results have confirmed the involvement of the tested microRNAs in the formation of BC malignancy degree, their association with tumor aggressiveness and have defined the prospects of further studies of the proposed microRNAs panel for their use as BC additional markers.

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Published

2024-08-28

How to Cite

Chekhun, V., Lukianova, N., Borikun, T., Bezdenezhnykh, N., Shepelenko, I., Bazas, V., & Klyusov, A. (2024). The Clinical Significance of Tumor MIR-122, -155, -182, and -200b Expression in Patients with Breast Cancer. Science and Innovation, 13(5), 63–69. https://doi.org/10.15407/scine13.05.063

Issue

Vol. 13 No. 5 (2017): Science and Innovation

Section

Research and Engineering Innovative Projects of the National Academy of Sciences of Ukraine

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