Nanodispersible ferromagnetic powder α-Fe synthesized from citrates of iron for medical applications
DOI:
https://doi.org/10.15407/dopovidi2018.01.043Keywords:
ferromagnetic powder, powder of iron, stabilityAbstract
A nanodispersible ferromagnetic powder α-Fe with the complex of physical and chemical properties (phase composition, high specific surface, chemical stability in plasma of blood and tissue liquid, active dissolution in gastric juice, chemical cleanness) necessary for the use in medical aims is created. The method of low-temperature (350—400 °C) decomposition/renewal of salts of citrates in the environment of hydrogen allowed us to get a nanodispersible ferromagnetic powder α-Fe with the specific surface of 31.4 m2/g. Its physical and chemical stability in plasma of blood is higher, as compared to standard powders α-Fe 3.200.26 and carbonic-iron (6-09-3000-78). The high specific surface and magnetic properties allow us to recommend a ferromagnetic powder α-Fe as a magnetic basis in the creation of composition materials for medical applications.
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Mytkina, V. A. (2009). Chemical transformation of magnetic carriers of medicinal preparations in model solutions and plasma of blood. Sibirskiy oncol. zhurn., Suppl. 1, pp. 136-137 (in Russian).
Rokko, M., Williams, R. & Allivisatos, P. (2002). Nanotechnology in the nearest decade. Prognosis of direction of researches. Moscow: Mir (in Russian).
Gilchrist, R.K., Shorey, W.D., Hanselman, R.C., De Peyster, F. A., Yang, J. & Medal, R. (1965). Effects of electromagnetic heating on internal viscera a preliminary to the treatment of human tumors. Ann. Surg., 161, No. 6, pp. 890-895. doi: https://doi.org/10.1097/00000658-196506000-00008
Andreas, S., Lubbe, M., Alexiou, S. & Bergemann, S. (2001). Clinical applications of magnetic drug targeting. J. Surg. Res., 95, No. 2, pp. 200-206. doi: https://doi.org/10.1006/jsre.2000.6030
Shapiro, B., Probst, R., Potts, H., Diver, D. & Lubbe, A. (2007). Control to concentrate drug-coated magnetic particles to deep-tissue tumors for targeted cancer. Proceeding of 46th IEEE Conference on Decigion and Control (pp. 3-30). New Orleans.
Jianwei, Z., Jianming, W., Tao, T., Gao, L., Haibin, C. & Shengquan, Z. (2006). Experimental study on magnetic drug targeting in treating cholangiocarcinoma based on internal magnetic fields. Chin.-Ger. J. Clin. Oncol., 5, No. 5, pp. 336-338. doi: https://doi.org/10.1007/s10330-006-0492-z
Moroz, S. K. & Jones, B. N. (2002). Numerical analysis of ferromagnetic embolisation hyperthermia for liver tumour therapy. J. Surg. Oncol., 80, No. 6, pp. 149. doi: https://doi.org/10.1002/jso.10118
Zvezdina, N. D., Martynova, L.E. & Zvezdin, K. A. (2007). New instruments are in medicine and biology : the use of magnetic nanoparticles. Nanotekhnika, 2, No. 10, pp. 33-42 (in Russian).
Liopo, V. A., Gympel, N. N. & Vasyliev, E. K. (1995). X-rayed phase analysis with the use of database. In Application of x-rays is in science and technique (pp. 125-131). Irkutsk: IGV (in Russian).
Chechernikov, V. I. (1969). Magnetic measuring. Moscow: Izd-vo Mosk. Un-ta (in Russian).
Hayat, M. A. (2000). Principles and techniques of electron microscopy: biological applications. Cambridge: Cambridge Univ. Press.
Panichkina, V. V. & Uvarova, I. V. (1973). Methods of control of dispersion and specific surface of metallic powders. Vol. 1-2. Kiev: Naukova Dumka (in Russian).
Tolochko, O. V., Lee, D. W., Choi, C.-J., Kim, D. & Arif, M. (2005). Structure and magnetic properties of iron based nanoparticles with oxide shells. Tech. Physs. Lett., 31, No. 9, pp. 779-781. doi: https://doi.org/10.1134/1.2061745
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