Determination of absolute configuration of dihydroindenols by enzymatic analysis and chiral HPLC
DOI:
https://doi.org/10.15407/dopovidi2022.04.077Keywords:
enzymatic deracemization, Burkholderia cepacia lipase, absolute configuration, Kazlauskas rule, chiral HPLCAbstract
Racemic 1,2-dihydroindenols were resolved into enantiomers using kinetically controlled esterification in the presence of Burkholderia cepacia lipase (BCL) biocatalyst. The resolution of halodihydroindenol acetates to enantiomers by enzymatic hydrolysis in the presence of Candida Antarctica B lipases immobilized on diatomite was also studied. To determine the absolute configuration of stereoisomers of halodihydroindenols, chiral HPLC analysis was used in combination with enzymatic analysis. The combined use of several methods increases the reliability in determining the absolute configuration of the studied compounds.
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