Antimicrobial properties and toxicity of imidazolium ionic liquids and their complexes with β-cyclodextrin
DOI:
https://doi.org/10.15407/dopovidi2015.03.107Keywords:
antimicrobial properties, ionic liquids, toxicity, β-cyclodextrinAbstract
Water soluble ionic liquid 1-dodecyl-3-methylimidazolium chloride and water resistant ionic liquid 1-dodecyl-3-methylimidazolium tetrafluoroborate have been synthesized. The inclusion complexes of ionic liquids with β-cyclodextrin in a molar ratio of 1 : 1 have been obtained. The structure of the complexes was confirmed by IR-spectroscopy and differential scanning calorimetry. Antimicrobial activity of both ionic liquids and their complexes with β-cyclodextrin has been established against Staphylococcus aureus (ATCC-25923), Escherichia coli (ATCC-25922), Pseudomonas aeruginosa (ATCC-27853), Candida albicans (M 885 ATCC 10231), and Candida albicans (clinical isolate) test-cultures. It is found that the complex formation of ionic liquids with β-cyclodextrin considerably reduces their toxicity.
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