A preparative method of synthesis of pyrazolylphenyl(phenoxy)acetic acids
DOI:
https://doi.org/10.15407/dopovidi2016.10.073Keywords:
2-(1N-pyrazol-3-yl)phenole, acetophenone, N-methyl pyrazol-3(or 5)-yl)phenoxyacetic acid, pyrazol-3(or 5)-yl)phenylacetic acid, pyrazoleAbstract
A new convenient and accessible method of synthesis of 2-(1H-pyrazol-3-yl)phenols through the heterocyclization of enaminoketone acetophenones with hydrazine hydrate and N-methylhydrazine is developed. The reactivity of obtained compounds is studied. It is demonstrated that the alkylation reactions followed by the hydrolysis result in high yields and are a convenient approach to the synthesis of pyrazolylphenylacetic and (N-methylpyrazolyl-3(or 5)-yl)phenoxyacetic acids.
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