The influence of a low-molecular (below 5 kD) fraction from newborn piglet hearts on biochemical parameters of rat blood serum after myocardial infarction
DOI:
https://doi.org/10.15407/dopovidi2016.08.116Keywords:
Actovegin, low-molecular fraction below 5 kDa from newborn pig hearts, myocardial infarctionAbstract
The influence of a low-molecular fraction (below 5 kD) isolated from newborn piglet hearts by the method of ultrafiltration on the cardiac muscle regeneration in rats with the model of catecholamine myocardial infarction in comparison with the reference drug Actovegin is investigated. Chromatographic and biochemical studies show that the compositions of low-molecular substances from the fraction and reference preparation Actovegin differ quantitatively and qualitatively. In in vivo studies, the significant differences in the effectivenesses of the action of drug Actovegin and the low-molecular fraction on the regenerative processes in myocardium after experimental infarction are revealed. In particular, it is established that the administration of the fraction below 5 kD to experimental animals causes a decrease and a normalization in the activity of marker enzymes of myocardial infarction in comparison with the control (saline) and preparation Actovegin.
Downloads
References
Rumyantseva S. A. Actovegin. New aspects of clinical application, Moscow, 2002: 3–9 (in Russian).
Pat. UA 69 652, A 61 K 35/14. A process for preparing low molecular weight fraction from cord blood of cattle, O. K. Gulevs'ky'j, N. M. Moiseyeva, O. S. Abakumova, I. J. Shchenyavs'ky'j, A.Yu. Nikol'chenko, O. L. Gorina, Applicant IPC&C, No u 201 112 006; Stated 12.10.2011, Publ. 10.05.2012, Bull. No 9 (in Ukrainian).
Rolik I. S. Fetal Organopreparations: Clinical Application. Guidelines for Doctors, Moscow: RegBioMed, 2003 (in Russian).
Brock T. D. Membrane Filtration, Moscow: Mir, 1987 (in Russian).
Belous A. M., Mokhamed A. N., Semenchenko A.Yu., Yavorskaya V. A. Reports of the National Academy of Sciences of Ukraine, 1997, 8: 177–181 (in Russian).
Colb V. G., Cameshnikov V. S. Directory of Clinical Chemistry, Minsk: Belarus, 1982 (in Russian).
Preclinical Studies of Medicines: Method. Recommendations, Kyiv: Avicena, 2001 (in Ukrainian).
Murashko V. V., Strutynsky A. V. Electrocardiography, Moscow: MEDpress, 2007 (in Russian).
Nazarenko G. I., Kyshkun A. A. Clinical Evaluation of Laboratory Results, Moscow: Medicina, 2002 (in Russian).
Menshikov V. V. Klin. Lab. Diagnostics, 1996, No 6: 51–52 (in Russian).
Titov V. N., Chernyadyeva I. F., Kotkina T. I. Lab. Delo, 1987, No 12: 883–893 (in Russian). PMid:2449565
Tzivoni D., Koukoui D., Guetta V., Novack L., Cowing G. Am. J. Cardiol., 2008, 101, No 6: 753–757. DOI: https://doi.org/10.1016/j.amjcard.2007.09.119, PMid:18328834
Turer A. T., Mahaffey K. W., Gallup D., Weaver W. D., Christenson R. H., Every N. R., Ohman E. M. Curr. Control. Trials Cardiovasc. Med., 2005, 6, No 1: 12. DOI: https://doi.org/10.1186/1468-6708-6-12, PMid:16115321 PMCid:PMC1236947
Bhimaraj A., Tang W. H. Heart Fail. Clin., 2012, 8: 101–111. DOI: https://doi.org/10.1016/j.hfc.2011.08.003, PMid:22108730 PMCid:PMC3227012
Letvickey P. P. Patol. Physiologiya i Experim. Therapiya, 2002, 2: 2–12 (in Russian).
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Reports of the National Academy of Sciences of Ukraine
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
